Who is stronger with facial injections? Ruidexi VS Youfaran| In-depth science popularization of CaHA regenerative filling

In recent years, the popularity of two types of CaHA (hydroxyapatite) injection materials has remained high in bone phase anti-aging track: import benchmarkRadiesse (commonly known as microcrystalline porcelain), domestic compliance headAphranel。The basic ingredients of the two are the same, and both focus on "immediate filling + long-term collagen regeneration". However, the microsphere technology, support, recovery period, and skin adaptation are very different. There is no absolute "who is stronger", only the difference between suitable people. This article disintegrates qualifications, core structure, shaping effect, recovery period, maintenance time, applicable parts, and budget in all dimensions to help you accurately select money.

1. Traceability of basic qualifications: originator of imports versus first domestic certificate

Radiesse

1. brand background: Research and development of Merz Mesch Aesthetics in Germany. It was certified by the US FDA in 2006. It has been clinical in 20 years around the world, with a total of more than 15 million tablets used, and has been marketed in compliance with regulations in more than 80 countries.
2. Domestic qualifications: In 2025, it will be approved to import Class III medical devices (CFDA Note I 20253130124), and domestic formal medical and beauty institutions can operate in compliance with regulations.
3. specifications: A single vial has a large capacity of 1.5ml, suitable for combined injection into multiple parts of the whole face, without the need for multiple vials.
4. formula: 30% solid CaHA microspheres + 70% CMC water-soluble gel carrier, ready to use when opening the bottle, no need for on-site deployment.

Aphranel

1. brand background: Shanghai Moyang Biological Self-Research,The first domestic CaHA approved for facial indications in ChinaIn February 2025, it obtained the NMPA Class III certificate (CFDA 20253130390) and simultaneously obtained the EU CE certification.
2. core patents: ACD-MT raspberry-shaped through-hole microspheres, PCD-ETT physically cross-linked gel, without chemical cross-linking agents, reducing the probability of allergic edema.
3. specifications: Two small volumes of 0.5ml/1ml are suitable for local fine shaping and a small amount of filling for the first time.
4. formula: The same 30% CaHA+70% CMC gel, premixed finished product, the operating threshold is lower.

2. Core hard-core differences: microspheres, support, regenerative logic (watershed in determining effects)

1. Microsphere structure (the most essential difference)

1. Redxi: 25-45μm smooth solid microspheres
2. Dense and solid structure, gentle degradation rate, slow and uniform collagen wrapping, making it difficult to fall back quickly; the microsphere has a wide particle size range, suitable for deep and large-area bony filling, and the overall stability is full.
3. Excellent flange: 30-35μm raspberry hollow porous microspheres
4. The surface is covered with pores, and the specific surface area is greatly increased, making it easier for fibroblasts to attach; at the same capacity, the number of microspheres is several times that of Redxi, so collagen regeneration takes effect faster and soft tissue fullness improves more significantly.

2. Support G'value (Shaping Hard Strength)

The G 'value represents the elastic hardness of the material. The higher the value, the stronger the three-dimensional shaping power of the bone:

1. Excellent flange: 5500Pa, which is about 10 times the support power of ordinary hyaluronic acid. The texture is "hard cement". It is erected immediately after injection. The bridge of the nose, eyebrow arch and chin can create clear cold bone lines, which are not easy to collapse or disperse.
2. Redxi: 3000Pa, the texture is flexible, the support is soft, and it will not be too stiff. It is suitable for soft and young bones. The outline is tiled and tightened in large areas, and the line transition is more natural and round.

3. Collagen Regeneration Speed & Maintenance Cycle

1. speed of onset of action
2. Youfaran> Redxi: The porous structure stimulates collagen faster. After 1-2 months of injection, you can see obvious skin brightening and soft tissue filling; Redxi's regeneration rhythm is gentle, and collagen gradually stabilizes after 3 months.
3. Maintenance duration
4. Redxi> Youfaran:
5. Redxi is maintained for 18-24 months at a single time. The metabolism of solid microspheres is slow and the acupuncture cycle is long. The large volume of 1.5ml is cost-effective for long-term anti-aging people;
6. After 12-18 months for a single shot, CMC gel drops slightly after about 3 months. The porous microspheres degrade faster, and the recharge period can be extended to 24-30 months.

3. Recovery period, swelling, and skin matching

1. Postoperative swelling (beauty seekers are most concerned about)

1. Excellent advantages in low edema: Pure physical cross-linked gel, no chemical cross-linking residues, weak water absorption and swelling, most people have slight soreness after surgery, and basically swelling within 1-3 days, and there is no pressure to socialize. It is the first choice for office workers and people who are afraid of recovery.
2. Redxi's swelling is more obvious: The carrier has higher viscosity, moderate swelling 1-2 weeks after surgery, and the initial vision will be full. A recovery period needs to be reserved, which is not suitable for emergency beautification needs.

2. Skin fit

1. Excellent flange: oily skin, prone to edema, first attempt to regenerate materials, thin skin and soft tissue depressions (cheek depressions, law lines); ultra-dilution method can be applied across the face to improve pore relaxation.
2. Ruidxi: Moderate thick skin, severe facial droop, large loss of bone mass, pursuit of long-term stability, and need to be modified with the contour of the whole face (improvement of mandibular margin and bone phase of the whole face).

4. Who is better at injection performance in various parts?

Youfaran is good at projects (strong shaping, fine bones)

1. Three-dimensional shaping of five senses: straight nose, high mountain roots, exquisite eyebrow arch, pointed chin, sharp lines without bloating;
2. Local depression: severe nasal base, deep law lines, strong support without falling back;
3. Shallow skin anti-aging: After dilution, apply the entire face to the dermis layer to tighten and brighten, and improve soft tissue dryness;
4. Fine-tuning of small parts: 0.5ml accurately improves local parts, has high fault tolerance rate, and is friendly to novices.

Ruidexi is good at projects (long-term contours, soft and large-scale anti-aging)

1. Fixed contour of the whole face: elevated mandibular margin, bedding the base of the zygomatic arch, and lifting the whole face bone, which is soft, natural and unobtrusive;
2. Large-area filling: Combined with multiple parts (eyebrow arch + nasal base + chin), 1 piece of 1.5ml covers the entire face;
3. Severe relaxation of mature muscles: the collagen lasts longer, the anti-aging life lasts longer, and frequent re-acupuncture is reduced;
4. Soft and young bone phase: Rejects the feeling of sharp bones and creates a round and smooth native bone phase.

Both have common taboos

Around the eyes, lips, and superficial fine lines (areas where the skin is too thin and frequently dynamic, prone to nodules and the touch of foreign bodies); dangerous areas with dense blood vessels must be operated in layers by senior doctors.

5. Summary of advantages and disadvantages, intuitive comparison

Red Xi's strengths and weaknesses

Advantage

1. Over the past 20 years of global clinical practice, safety data is sufficient, and the adverse reaction rate of granuloma and nodule is <0.1%;
2. 1.5ml has a large capacity, enough for a single tube for full face reconstruction, long-term maintenance, and less acupuncture;
3. Solid microspheres are highly stable, have lower risks of migration and dispersion, and are not prone to collapse in the long term;
4. The texture is soft and suitable for beauty seekers who pursue a sense of natural origin and resist sharp bone lines.
5. Shortboard
6. The postoperative swelling period is long (1-2 weeks) and the recovery period is obvious;
7. The G 'value is low, and the ultimate three-dimensional bony shaping is weaker than that of the excellent flange;
8. The total price of a single item is higher, and the cost of first small adjustments is not cost-effective.

Advantages and disadvantages of excellent flanges

Advantage

1. The first domestic compliant facial CaHA has a higher cost performance ratio. It is small in 0.5ml and has low trial and error costs;
2. Ultra-high support, bony shapes the ceiling, creating a three-dimensional cold facial features;
3. Low edema, short recovery period, rapid and normal social interaction after surgery;
4. Porous microspheres regenerate collagen faster and have an intuitive effect on improving dry skin.
5. Shortboard
6. The basic maintenance period is shorter and requires regular replenishment;
7. The texture is too hard, and excessive injection may easily have stiff lines and a fake feeling;
8. Small capacity, full face contour reconstruction requires multiple branches to be stacked.

6. The ultimate choice guide: Should you choose Redhi or Youfaran?

Priority is given to excellent flanges if you meet the following conditions

1. It was the first time I used CaHA for regenerative filling, and I just wanted to make local adjustments, so the budget was limited;
2. Want a high three-dimensional bone appearance: straight nose, eyebrow arch, delicate chin, and pursue clear outlines;
3. Office workers, social needs, cannot accept a long swelling recovery period;
4. Facial soft tissues are dry, cheeks are concave, and deep lines are deep. You want to quickly activate the collagen-rich skin;
5. It is easy to edema and has oily skin. I am afraid that my face will swell into steamed buns after being beaten.

Priority will be given to Redxi if you meet the following conditions

1. With severe facial relaxation and large loss of bone mass in mature muscles, use full face contours to resist aging;
2. Pursue long-term effects, do not want to replenish acupuncture frequently, and give priority to long-term anti-aging cost performance;
3. I like soft, round and original bone appearance, and do not want sharp and abrupt facial features;
4. Multi-site combined filling (eyebrow arch + nasal base + mandibular margin) requires a large volume of materials;
5. There is sufficient time to accept a 1-2 week postoperative swelling recovery period.

7. Key reminders for injection to avoid pits

1. Both are insoluble materials. Before injection, face-to-face diagnosis must be made to accurately measure the dose and prevent overfilling;
2. Doctors who hold three types of medical aesthetic operation qualifications and are familiar with CaHA-level methods must be selected. Only by deep injection into the periosteal layer can they exert support;
3. Do not mix unknown powder regenerated needles. Redxi and Youflange are pre-mixed finished products, which do not require on-site deployment to avoid the risk of agglomeration;
4. Avoid high temperature saunas and vigorously rub the filling area for one month after surgery to ensure uniform collagen regeneration.